Document Detail


Acoustical properties of individual liposome-loaded microbubbles.
MedLine Citation:
PMID:  23196203     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A comparison between phospholipid-coated microbubbles with and without liposomes attached to the microbubble surface was performed using the ultra-high-speed imaging camera (Brandaris 128). We investigated 73 liposome-loaded microbubbles (loaded microbubbles) and 41 microbubbles without liposome loading (unloaded microbubbles) with a diameter ranging from 3-10 μm at frequencies ranging from 0.6-3.8 MHz and acoustic pressures ranging from 5-100 kPa. The experimental data showed nearly the same shell elasticity for the loaded and unloaded bubbles, but the shell viscosity was higher for loaded bubbles compared with unloaded bubbles. For loaded bubbles, a higher pressure threshold for the bubble vibrations was noticed. In addition, an "expansion-only" behavior was observed for up to 69% of the investigated loaded bubbles, which mostly occurred at low acoustic pressures (≤30 kPa). Finally, fluorescence imaging showed heterogeneity of liposome distributions of the loaded bubbles.
Authors:
Ying Luan; Telli Faez; Erik Gelderblom; Ilya Skachkov; Bart Geers; Ine Lentacker; Ton van der Steen; Michel Versluis; Nico de Jong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  38     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2174-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Affiliation:
Biomedical Engineering Thoraxcentre, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: y.luan@erasmusmc.nl.
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