Document Detail


Acoustical modulation of electrically evoked otoacoustic emission in intact gerbil cochlea.
MedLine Citation:
PMID:  9667426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to study the interaction between mechanical-electrical and electrical-mechanical transductions of outer hair cells (OHCs) in vivo, we observed the acoustically induced changes in the electrically evoked otoacoustic emission (EEOAE). One pole of a bipolar electrode was placed in the round window niche and the other pole on the surface of the first cochlear turn in the gerbil. A microphone and a speaker were used to monitor the EEOAE and to deliver an acoustical tone, respectively. It was found that a high sound level acoustical tone enhanced the EEOAE fine structure at frequencies below the acoustical frequency, and suppressed the overall level of the EEOAE at frequencies above the acoustical frequency. In addition, the EEOAE at frequencies approximately one half octave lower than the acoustical frequencies were relatively more enhanced or showed relatively less suppression than at other frequencies. The amplitudes of these changes had a positive relationship with acoustical tone levels. Furosemide eliminated the acoustically caused EEOAE change indicating that the acoustically caused change in the EEOAE is a phenomenon of the normal cochlea. One possible mechanism for the results is that the electrically and acoustically evoked basilar membrane (BM) vibrations interact at the EEOAE generation site and change the local mechanical and electrical properties. The second possible mechanism is that the acoustical stimulus creates an impedance discontinuity at its characteristic frequency location leading to a change in the reflected electrically evoked traveling wave, which may enhance or suppress the EEOAE by the vector summation of two waves.
Authors:
T Ren; A L Nuttall
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  120     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-17     Completed Date:  1998-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  7-16     Citation Subset:  IM    
Affiliation:
Oregon Hearing Research Center (NRC04), Department of Otolaryngology and Head and Neck Surgery, Oregon Health Sciences University, Portland 97201-3098, USA. rent@ohsu.edu
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Cochlea / cytology,  physiology*
Cochlear Microphonic Potentials / drug effects,  physiology
Diuretics / pharmacology
Electric Stimulation
Evoked Potentials, Auditory / physiology*
Furosemide / pharmacology
Gerbillinae
Hair Cells, Auditory, Outer / drug effects,  physiology*
Otoacoustic Emissions, Spontaneous / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
2 P01 00078//PHS HHS; 5 R01 DC 000141/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Diuretics; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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