Document Detail


Acoustical analysis of mechanical heart valve sounds for early detection of malfunction.
MedLine Citation:
PMID:  20573536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mechanical heart valves carry the disadvantage of lifelong antithrombotic therapy, due to the high risk of thrombus formation on the valve surface. Current diagnostic methods are incapable of detecting thrombus formation in an early stage. This article investigates a new diagnostic method, based on the analysis of the acoustic signal produced by the valve. This method should be capable of early detection of malfunction, thus permitting targeted medication and reducing valve-related complications and mortality. A measurement setup assuring optimal signal quality was developed, and a signal analysis program was implemented and validated on an in vitro mock circulatory loop. Next, four sheep were implanted with a bileaflet mechanical valve. The signals of their valves developing thrombosis were assessed on a weekly basis before explantation. Three sheep were sacrificed shortly after detection of malfunction according to the newly developed method. In each case, thrombus or membrane formation was detected on the leaflets upon explantation. In one sheep, no malfunction was found in the analysis, which was also confirmed by the condition of the valve upon explantation. These preliminary results indicate that acoustical analysis of mechanical heart valves permits early detection of valvular malfunction. Further research with more in vitro and animal testing is required to statistically validate these findings.
Authors:
Nele Famaey; Korijn Defever; Paul Bielen; Willem Flameng; Jos Vander Sloten; Paul Sas; Bart Meuris
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Publication Detail:
Type:  Journal Article     Date:  2010-06-22
Journal Detail:
Title:  Medical engineering & physics     Volume:  32     ISSN:  1873-4030     ISO Abbreviation:  Med Eng Phys     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  England    
Other Details:
Languages:  eng     Pagination:  934-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 IPEM. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Division of Biomechanics and Engineering Design, Katholieke Universiteit Leuven, Belgium. nele.famaey@mech.kuleuven.be
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MeSH Terms
Descriptor/Qualifier:
Acoustics*
Animals
Heart Valve Prosthesis*
Prosthesis Failure* / adverse effects
Signal Processing, Computer-Assisted*
Sound*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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