| Acoustic source separation for the detection of coronary artery sounds. | |
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MedLine Citation:
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PMID: 22225070 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Coronary artery disease (CAD) is the leading cause of death in the United States, being responsible for more than 20% of all deaths in the country. This is in large part due to the difficulty of diagnostic screening for CAD. Phonoangiography seeks to detect CAD via the acoustic signature associated with turbulent flow near an abnormally constricted, or stenosed, region. However, the usefulness of the technique is severely hindered by the low strength of the CAD signal compared to the background noise within the chest. In this work, acoustic finite element analysis (FEA) was performed on physiologically accurate chest geometries to demonstrate the feasibility of an original acoustic source separation methodology for isolating coronary sounds. This approach is based upon pseudoinversion of mixing matrices determined through a combination of experiment and computation. This allows calculation of the sound emitted by the coronary arteries based upon measurements of the acoustic velocity on the chest surface. This work demonstrates the feasibility of such a technique computationally and examines the vulnerability of the proposed approach to measurement errors. |
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Authors:
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Daniel B Cooper; Michael J Roan; Pavlos P Vlachos |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 130 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 4158 Citation Subset: IM |
Affiliation:
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School of Biomedical Engineering and Sciences, Virginia Tech, 100 Randolph Hall, Blacksburg, Virginia 24061. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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