Document Detail

Acoustic schwannoma and pregnancy: a DNA flow cytometric, steroid hormone receptor, and proliferation marker study.
MedLine Citation:
PMID:  7603272     Owner:  NLM     Status:  MEDLINE    
For a long time, it has been speculated that pregnancy stimulates the growth of acoustic schwannomas. To test this hypothesis, immunohistochemical stains for estrogen receptor, progesterone receptor, and proliferating cell nuclear antigen (PCNA) were performed. Flow cytometric studies for DNA ploidy and S-phase fraction determinations were also performed. The study subjects included 6 female patients with unilateral acoustic tumors; at the time of tumor removal, 1 woman was pregnant and the other 5 women were 2 to 10 months postpartum. The age-sex-matched control group consisted of 6 men and 12 nonpregnant women, all with acoustic schwannomas similar in size to those of the study group. The study found no statistically significant association between the presence or quantity of estrogen or progesterone receptors and pregnancy, DNA ploidy, proliferation indices, or clinical data. Based on PCNA indices, large tumors tended to be less "biologically active" than small lesions (P < .01). The authors concluded that pregnancy does not significantly stimulate the cellular growth of acoustic schwannomas.
C W Beatty; B W Scheithauer; J A Katzmann; P C Roche; K S Kjeldahl; M J Ebersold
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  105     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-08     Completed Date:  1995-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  693-700     Citation Subset:  IM    
Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minn 55905, USA.
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MeSH Terms
Biological Markers / analysis*
Cell Division
DNA, Neoplasm / analysis
Flow Cytometry
Matched-Pair Analysis
Neuroma, Acoustic / chemistry,  pathology*
Pregnancy Complications, Neoplastic / metabolism,  pathology*
Proliferating Cell Nuclear Antigen / analysis
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis
Reg. No./Substance:
0/Biological Markers; 0/DNA, Neoplasm; 0/Proliferating Cell Nuclear Antigen; 0/Receptors, Estrogen; 0/Receptors, Progesterone

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