Document Detail

Acoustic droplet vaporization for temporal and spatial control of tissue occlusion: a kidney study.
MedLine Citation:
PMID:  16212249     Owner:  NLM     Status:  MEDLINE    
Acoustic droplet vaporization (ADV) has been introduced with the potential application of tumor treatment via occlusion and subsequent necrosis. New Zealand White rabbits were anesthetized, and their left kidney was externalized. An imaging array and single-element transducer were positioned in a tank with direct access to the kidney's vasculature and renal artery. Filtered droplet emulsions (diameter <6 microm) were injected intra-arterially (IA) into the left heart during insonification of the renal artery, and the extent of blood flow reduction by ADV was compared to the untreated right kidney. Flow cytometry (using colored microspheres) of kidney tissue samples and reference blood from the femoral artery allowed the quantitative estimation of regional blood flow. A maximum regional blood flow reduction in the treated region of >90% and an average organ perfusion reduction of >70% was achieved using ADV. After treatment of the left kidney, the control kidney on the contralateral side showed a maximum decrease in regional blood flow of 18% relative to the pre-ADV baseline. Image-based hyper-echogenicity from ADV of IA injections was monitored for approximately 90 minutes, and cortex perfusion was reduced by >60% of its original value for more than 1 hour. This could be enough time for the onset of cell death and possible tumor treatment via ischemic necrosis. Moreover, currently used radiofrequency tissue ablation-based tumor treatment could benefit from ADV due to the decreased heat loss via vascular cooling.
Oliver D Kripfgans; Catherine M Orifici; Paul L Carson; Kimberly A Ives; O Petter Eldevik; J Brian Fowlkes
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Publication Detail:
Type:  Evaluation Studies; In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  IEEE transactions on ultrasonics, ferroelectrics, and frequency control     Volume:  52     ISSN:  0885-3010     ISO Abbreviation:  IEEE Trans Ultrason Ferroelectr Freq Control     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-10-10     Completed Date:  2005-11-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9882735     Medline TA:  IEEE Trans Ultrason Ferroelectr Freq Control     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1101-10     Citation Subset:  IM    
University of Michigan, Radiology Department, Ann Arbor, MI, USA.
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MeSH Terms
Embolization, Therapeutic / methods*
Renal Artery / physiology*,  ultrasonography*
Renal Circulation / physiology*
Ultrasonic Therapy / methods*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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