Document Detail

Acoustic analysis in the differentiation of Parkinson's disease and major depression.
MedLine Citation:
PMID:  1447729     Owner:  NLM     Status:  MEDLINE    
In its early stages, Parkinson's disease (P.D.) may be difficult to distinguish from major depression (M.D.) leading to inappropriate management. Both illnesses are characterized by psychomotor retardation. The neurovegetative symptoms used to diagnose M.D. are not specific and in P.D. may be due to the physical illness itself. Currently, differentiation of the two disorders relies on subjective clinical observation. Improved diagnostic accuracy based on more objective data is needed. To this end, this study used computerized acoustic analysis to contrast speech patterns in P.D. and M.D. The sample consisted of 30 P.D. patients without depression or dementia, 30 patients with uncomplicated M.D., and 31 normal controls, each 60 years of age or over. Of the acoustic variables studied, M.D. patients had significantly reduced rates of speech compared with P.D. patients. The data suggest that this temporal measure of speech may be useful in the differentiation of P.D. and M.D.
A J Flint; S E Black; I Campbell-Taylor; G F Gailey; C Levinton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psycholinguistic research     Volume:  21     ISSN:  0090-6905     ISO Abbreviation:  J Psycholinguist Res     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-29     Completed Date:  1992-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0333506     Medline TA:  J Psycholinguist Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-9     Citation Subset:  IM    
Dept. of Psychiatry, Toronto General Hospital, Ontario, Canada.
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MeSH Terms
Articulation Disorders
Depressive Disorder / classification,  diagnosis*,  physiopathology
Parkinson Disease / classification,  diagnosis*,  physiopathology
Psychiatric Status Rating Scales
Speech Acoustics*
Speech Production Measurement
Time Factors
Verbal Behavior

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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