Document Detail

Acoustic radiation force impulse (ARFI) imaging of zebrafish embryo by high-frequency coded excitation sequence.
MedLine Citation:
PMID:  22101757     Owner:  NLM     Status:  MEDLINE    
Acoustic radiation force impulse (ARFI) imaging has been developed as a non-invasive method for quantitative illustration of tissue stiffness or displacement. Conventional ARFI imaging (2-10 MHz) has been implemented in commercial scanners for illustrating elastic properties of several organs. The image resolution, however, is too coarse to study mechanical properties of micro-sized objects such as cells. This article thus presents a high-frequency coded excitation ARFI technique, with the ultimate goal of displaying elastic characteristics of cellular structures. Tissue mimicking phantoms and zebrafish embryos are imaged with a 100-MHz lithium niobate (LiNbO₃) transducer, by cross-correlating tracked RF echoes with the reference. The phantom results show that the contrast of ARFI image (14 dB) with coded excitation is better than that of the conventional ARFI image (9 dB). The depths of penetration are 2.6 and 2.2 mm, respectively. The stiffness data of the zebrafish demonstrate that the envelope is harder than the embryo region. The temporal displacement change at the embryo and the chorion is as large as 36 and 3.6 μm. Consequently, this high-frequency ARFI approach may serve as a remote palpation imaging tool that reveals viscoelastic properties of small biological samples.
Jinhyoung Park; Jungwoo Lee; Sien Ting Lau; Changyang Lee; Ying Huang; Ching-Ling Lien; K Kirk Shung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-19
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  40     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-07-16     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  907-15     Citation Subset:  IM    
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MeSH Terms
Acoustics / instrumentation
Embryo, Nonmammalian / anatomy & histology*
Whole Body Imaging / instrumentation*,  methods*
Zebrafish / anatomy & histology*,  embryology*
Grant Support
P41 EB002182/EB/NIBIB NIH HHS; P41 EB002182-14/EB/NIBIB NIH HHS; P41 EB002182-14S1/EB/NIBIB NIH HHS; P41-EB2182/EB/NIBIB NIH HHS; R01 HL079976/HL/NHLBI NIH HHS; R01 HL079976-03/HL/NHLBI NIH HHS; R01-EB012058-01A1/EB/NIBIB NIH HHS

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