Document Detail

Acotiamide, a novel gastroprokinetic for the treatment of patients with functional dyspepsia: postprandial distress syndrome.
MedLine Citation:
PMID:  23061703     Owner:  NLM     Status:  In-Data-Review    
Functional dyspepsia (FD) is a highly prevalent condition with major socioeconomic and healthcare impact. To date, no pharmacological treatment for FD has been approved. The Rome consensus proposed to subdivide FD into postprandial distress syndrome (PDS), characterized by meal-related symptoms and epigastric pain syndrome, characterized by pain and burning. Acotiamide (Z-338 or YM443) is a new drug, developed for the treatment of FD. Acotiamide enhances acetylcholine release from enteric neurons through muscarinic receptor antagonism and acetycholinesterase inhibition, thereby enhancing gastric emptying and gastric accommodation. Acotiamide was evaluated in FD in clinical studies in Europe, Japan and the USA, beneficial effects were observed for the PDS symptoms of postprandial fullness and early satiation, with a dose of 100 mg three-times a day. A 4-week placebo-controlled Phase III study in PDS patients in Japan confirmed efficacy of acotiamide in relieving postprandial fullness, early satiation and upper abdominal bloating.
Ege Altan; Tatsuhiro Masaoka; Ricard Farré; Jan Tack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of gastroenterology & hepatology     Volume:  6     ISSN:  1747-4132     ISO Abbreviation:  Expert Rev Gastroenterol Hepatol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278199     Medline TA:  Expert Rev Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  533-44     Citation Subset:  IM    
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, 3000 Leuven, Belgium.
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