Document Detail

Acnegenicity testing in rabbits. An objective quantification method.
MedLine Citation:
PMID:  2413680     Owner:  NLM     Status:  MEDLINE    
An objective method for the quantification of follicular hyperkeratosis is proposed for the rabbit ear assay of acnegenicity. The area (area%) of hyperkeratinized follicles, covering a stereomicroscopic photo of the epidermis, is proposed for the quantification of the response. The uniformity of two observers' quantification was evaluated in six tested formulations. The quantification of the response in area% was found to be a suitable and objective alternative to visual scoring on a graded scale. The median relative difference between two observers' area%-quantification was found to be 26%, and there was no statistically significant difference between the two observers' quantification (p greater than 0.10). An area% of 2, 7, and 15 is preliminarily suggested to be equivalent to the lower limit for scores 1, 2 and 3 respectively.
E Bechgaard
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  65     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  282-6     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris / chemically induced*,  pathology
Disease Models, Animal
Drug Evaluation, Preclinical / methods
Myristates / toxicity
Reg. No./Substance:
0/Myristates; 110-27-0/isopropyl myristate

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