Document Detail


Acne and its drug treatment
MedLine Citation:
PMID:  2145653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The most common disease of the pilosebaceous follicle is acne vulgaris. The primary detectable pathologic defect in acne is abnormal keratinization of the follicular epithelium, resulting in a retention hyperkeratosis. The primary lesion produced by this process, the comedo, ist the precursor of most other acne lesions. These include inflammatory papules, pustules and nodules. Treatment principles are directed against known pathogenic factors. The major topical modalities that are currently being used include tretinoin, benzoyl peroxide and topical antibiotics. Benzoyl peroxide is a powerful antibacterial agent. Topical erythromycin and clindamycin appear to have equivalent efficacy. A major treatment advance has been heralded by the use of oral 13-cis retinoic acid (isotretinoin) in the management of patients with severe nodulocystic acne, acne conglobata and acne fulminans. Isotretinoin is teratogenic and should not be given to women of childbearing age.
Authors:
S A Büchner
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Therapeutische Umschau. Revue thérapeutique     Volume:  47     ISSN:  0040-5930     ISO Abbreviation:  Ther Umsch     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-11-09     Completed Date:  1990-11-09     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  0407224     Medline TA:  Ther Umsch     Country:  SWITZERLAND    
Other Details:
Languages:  ger     Pagination:  670-4     Citation Subset:  IM    
Affiliation:
Dermatologische Universitätsklinik Basel.
Vernacular Title:
Die Akne und ihre medikamentöse Behandlung.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / classification,  drug therapy*
Adolescent
Adult
Androgen Antagonists / therapeutic use
Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents, Local / therapeutic use
Benzoyl Peroxide / therapeutic use
Dermatologic Agents / therapeutic use*
Humans
Isotretinoin / therapeutic use
Tretinoin / therapeutic use
Chemical
Reg. No./Substance:
0/Androgen Antagonists; 0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 0/Dermatologic Agents; 302-79-4/Tretinoin; 4759-48-2/Isotretinoin; 94-36-0/Benzoyl Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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