Document Detail

Acne in infancy and acne genetics.
MedLine Citation:
PMID:  12566802     Owner:  NLM     Status:  MEDLINE    
Acne is a disease that can be seen in the first year of age, early childhood, prepubertal age and puberty. Neonatal acne is due mainly to considerable sebum excretion rate, and infantile acne because of high androgens of adrenal origin in girls and of adrenal and testes in boys. These pathogenic mechanisms are characteristic in these ages. Important factors like early onset of comedones and high serum levels of dehydroepiandrosterone sulfate are predictors of severe or long-standing acne in prepubertal age. Hereditary factors play an important role in acne. Neonatal, nodulocystic acne and conglobate acne has proven genetic influences. Postadolescent acne is related with a first-degree relative with the condition in 50% of the cases. Chromosomal abnormalities, HLA phenotypes, polymorphism of human cytochrome P-450 1A1 and MUC1 gene are involved in the pathogenesis of acne. Several other genes are being studied.
Maria I Herane; Iwao Ando
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  206     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2003  
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-08-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Dermatology, West Unit Faculty of Medicine, Hospital San Juan de Dios, University of Chile, Santiago, Chile.
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MeSH Terms
Acne Vulgaris* / drug therapy,  genetics,  physiopathology
Child, Preschool
Cytochrome P-450 CYP1A1 / genetics*
Infant, Newborn
Keratolytic Agents / therapeutic use
Polymorphism, Genetic
Sebaceous Glands / metabolism
Tretinoin / therapeutic use
Reg. No./Substance:
0/Keratolytic Agents; 302-79-4/Tretinoin; EC P-450 CYP1A1

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