Document Detail


Acitretin embryopathy: a case report.
MedLine Citation:
PMID:  15470719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acitretin is an aromatic retinoid analog of vitamin A. Drugs of this group are well-known teratogenic agents. Nevertheless, acitretin embryopathy has been described only in fetuses. CASE: An infant was exposed to 10 mg/day of acitretin from the beginning of pregnancy until the 10th gestational week. At term, the newborn showed the following abnormalities: microcephaly, epicanthal folds, low nasal bridge, high palate, cup-shaped ears, anteverted nostrils, atrial septal defect, and bilateral sensorineural deafness. At 18 months of age, the patient showed microcephaly and neurodevelopmental delay. CONCLUSIONS: Our patient shows a pattern of anomalies resembling that observed in isotretinoin- and etretinate-exposed children. After ingestion, acitretin is partially converted into etretinate, and etretinate is partially metabolized into acitretin. A similar phenotype would therefore be expected after prenatal exposure to either drug. Moreover, in the present case, teratogenic effects were observed even though the dose was lower than in the previously reported acitretin embryopathy cases. Therefore, we propose that different retinoids, acitretin included, produce only one malformation pattern with variable phenotypic expression.
Authors:
Pablo Barbero; Vanesa Lotersztein; Ruben Bronberg; Miriam Perez; Liliana Alba
Related Documents :
18818179 - No association found between use of very large doses of diazepam by 112 pregnant women ...
15289149 - Latanoprost exposure in pregnancy.
1606119 - The effects of fetal exposure to danazol.
9646009 - Clinical pharmacokinetics of neuromuscular relaxants in pregnancy.
20668039 - Treatment of hyperthyroidism in pregnancy and birth defects.
3234759 - Pollen immunotherapy during pregnancy: long-term follow-up of offsprings.
7936839 - Aminoterminal propeptide of type iii procollagen in cord blood and amniotic fluid of ap...
3583089 - Essential metal balance and retention during the second half of pregnancy in the rat.
18335509 - Four-dimensional sonography with b-flow imaging and spatiotemporal image correlation fo...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  70     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2005-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  831-3     Citation Subset:  IM    
Copyright Information:
(c) 2004 Wiley-Liss, Inc.
Affiliation:
Línea Salud Fetal, Servicio de Información de Agentes Teratogénicos, Centro Nacional de Genética Médica, Buenos Aires, Argentina. pablo@genes.gov.ar
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / chemically induced*
Acitretin / toxicity*
Embryo, Mammalian / drug effects*
Female
Hearing Loss, Sensorineural / chemically induced*
Humans
Infant
Teratogens / toxicity*
Chemical
Reg. No./Substance:
0/Teratogens; 55079-83-9/Acitretin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Parameter oscillations in a very high gravity medium continuous ethanol fermentation and their atten...
Next Document:  Regulated expression of VP16CREB in neuroblastoma cells: analysis of differentiation and apoptosis.