Document Detail


Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour.
MedLine Citation:
PMID:  21893434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acinar cell carcinomas of the pancreas are rare neoplasms. Usually diagnosed at an advanced stage, in general they are large solid pancreatic tumours with an average size of more than 10 cm.
AIMS AND RESULTS: We report 3 cases of acinar cell carcinomas involving the peripancreatic lymph nodes, the liver hilum and the colon respectively, without clinical or pathological evidence of pancreatic tumours. These highly cellular neoplasms showed a predominantly acinar cell differentiation intermingled with a ductal component, with intracellular or extracellular mucin production by at least 25% of tumour cells. In addition, one case showed endocrine differentiation. Diffuse immunoreactivity for acinar enzymes trypsin and chymotrypsin was present in all cases.
CONCLUSION: The occurrence of acinar cell carcinomas outside the pancreas underlines the notion that acinar cell carcinomas may originate in extrapancreatic sites and probably develop from heterotopic or metaplastic pancreatic foci present along the biliary tract.
Authors:
Benoît Terris; Muriel Genevay; Alexandre Rouquette; Anne Audebourg; Gilles Mentha; Bertrand Dousset; Laura Rubbia-Brandt
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-09-03
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  43     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-04     Completed Date:  2012-03-29     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  971-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Service d'Anatomie et Cytologie Pathologiques, Hôpital Cochin, Université Paris Descartes, Paris, France. benoit.terris@cch.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Acinar Cell / diagnosis,  pathology*,  secondary,  surgery
Chymotrypsin / analysis
Humans
Immunohistochemistry
Liver Neoplasms / secondary*
Lymphatic Metastasis
Male
Middle Aged
Pancreatic Neoplasms / diagnosis,  pathology*,  surgery
Retroperitoneal Neoplasms / secondary*
Trypsin / analysis
Chemical
Reg. No./Substance:
EC 3.4.21.1/Chymotrypsin; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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