Document Detail

Acinar and Conductive Ventilation Heterogeneity in Severe CF Lung Disease: Back to the Model.
MedLine Citation:
PMID:  23692927     Owner:  NLM     Status:  Publisher    
Severe convective ventilation heterogeneity occurring in CF lung disease requires a modified method to determine acinar and conductive components of ventilation heterogeneity from normalized phaseIII slope (Sn) curves. Modified Sacin* and Scond* (as opposed to standard Sacin and Scond) are proposed and interpreted on the basis of 2 conceptual mechanisms: (a) flow asynchrony between two convection-dependent units with a different specific ventilation, but with an identical acinus inside each unit (generating an identical diffusion-convection-dependent portion of Sn); (b) different specific ventilation (without any flow asynchrony) between two convection-dependent units with the worst ventilated unit containing an abnormal acinus generating the greatest diffusion-convection-dependent portion of Sn. In CF patients with an abnormal lung clearance index (LCI), Scond* (but not Scond) and Sacin* were significant contributors to LCI (β(Scond*)=0.70;β(Sacin*)=0.49;P<0.001 for both). Mechanism(a) can entirely account for experimental Scond* values, while mechanism(b) implies that experimental Sacin* values are likely dominated by peripheral ventilation heterogeneity in the best ventilated portions of the lung.
Sylvia Verbanck; Manuel Paiva; Daniel Schuermans; Anne Malfroot; Walter Vincken; Eef Vanderhelst
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-18
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Respiratory Division, University Hospital UZ Brussel, 1090 Brussels, Belgium. Electronic address:
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