| Acidity surrounding the squamocolumnar junction in GERD patients: "acid pocket" versus "acid film". | |
| | |
MedLine Citation:
|
PMID: 17714553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: This study aimed to localize the gastric-to-esophageal pH transition point relative to the squamocolumnar junction (SCJ) and esophagogastric junction (EGJ) high-pressure zone in controls and GERD patients. METHODS: Ten controls and 10 GERD patients were studied. Subjects had an endoclip placed at the SCJ prior to a pH catheter pull-through (upright and supine) during concurrent fluoroscopy before and after consuming a standardized meal. Six controls and 6 GERD patients also underwent concurrent manometry. The relative positions of the SCJ, EGJ high-pressure zone, and pH transition points were analyzed. RESULTS: Most controls and GERD patients exhibited an unbuffered acidified segment in the proximal stomach postprandially. The proximal pH transition point was confined distal to the SCJ in control subjects, regardless of posture or meal state. GERD patients exhibited a more proximal pH transition point, extending above the SCJ and EGJ high-pressure zone in the supine position, especially postprandially. However, the high-pressure zone was intact. CONCLUSION: A short segment of unbuffered acidity of unknown volume exists after meals in the proximal stomach. In controls, the unbuffered acidic segment is contained distal to the SCJ while in the GERD patients it extended into and even across the EGJ high-pressure zone. However, this extension through the EGJ in GERD patients occurred in the context of an intact sphincter suggesting that this is best conceptualized as an acid "film" rather than a "pocket." This observation may help explain the propensity of the distal esophageal mucosa to lesions of reflux disease. |
| | |
Authors:
|
John E Pandolfino; Qing Zhang; Sudip K Ghosh; Jennifer Post; Monika Kwiatek; Peter J Kahrilas |
Related Documents
:
|
9380063 - Severe constipation in parkinson's disease relieved by botulinum toxin. 8623013 - Rectal adaptation to distention: implications for the determination of perception thres... 7751413 - Treatment of mild hypertension with low once-daily doses of a sustained-release capsule... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-08-21 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 102 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-28 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 2633-41 Citation Subset: IM |
Affiliation:
|
Northwestern University's Feinberg School of Medicine, Chicago, Illinois 60611, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Case-Control Studies Esophageal pH Monitoring / instrumentation* Esophagogastric Junction* Esophagoscopy Female Fluoroscopy Gastroesophageal Reflux / physiopathology* Humans Hydrogen-Ion Concentration Male Manometry Middle Aged Postprandial Period / physiology Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
|
K23 DK062170-01/DK/NIDDK NIH HHS; R01 DC00646/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory b...
Next Document: Strong protective effect of DR3 against ulcerative colitis in the Spanish population.