Document Detail

Acidification of the interior of Ehrlich ascites tumor cells by nigericin inhibits DNA synthesis.
MedLine Citation:
PMID:  3609324     Owner:  NLM     Status:  MEDLINE    
In Ehrlich ascites carcinoma cells, acidification of the cytoplasm down to pH 6.2-6.3 arrests DNA synthesis. Such acidification can be obtained by decreasing the pH outside the cell or, alternatively, by addition of a micromolar concentration of the K+/H+ antiporter nigericin. Thus, nigericin may be regarded as a new type of cytostatic, the effect of which is mediated by alteration of the intracellular pH.
L B Margolis; I A Rozovskaja; V P Skulachev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  220     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-23     Completed Date:  1987-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  288-90     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Carcinoma, Ehrlich Tumor / physiopathology
Cytoplasm / physiology
DNA / biosynthesis*
Hydrogen-Ion Concentration*
Nigericin / pharmacology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 28380-24-7/Nigericin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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