Document Detail


Acidic triazoles as soluble guanylate cyclase stimulators.
MedLine Citation:
PMID:  21924901     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF(3) triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.
Authors:
Lee R Roberts; Paul A Bradley; Mark E Bunnage; Katherine S England; David Fairman; Yvette M Fobian; David N A Fox; Geoff E Gymer; Steven E Heasley; Jerome Molette; Graham L Smith; Michelle A Schmidt; Michael A Tones; Kevin N Dack
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-28
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Worldwide Medicinal Chemistry, Pfizer, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
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