| Acidic triazoles as soluble guanylate cyclase stimulators. | |
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MedLine Citation:
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PMID: 21924901 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF(3) triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25. |
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Authors:
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Lee R Roberts; Paul A Bradley; Mark E Bunnage; Katherine S England; David Fairman; Yvette M Fobian; David N A Fox; Geoff E Gymer; Steven E Heasley; Jerome Molette; Graham L Smith; Michelle A Schmidt; Michael A Tones; Kevin N Dack |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-28 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Worldwide Medicinal Chemistry, Pfizer, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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