| Acidic fibroblast growth factor prevents post-axotomy neuronal death of the newborn rat facial nerve. | |
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MedLine Citation:
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PMID: 8552294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The death of facial motoneurons after axotomy provides a useful tool for studying neurotrophic factors which could prevent motoneuron loss in vivo. The right facial nerve trunk before the postauricular nerve branching of newborn rats was transected at its extracranial exit, and topically treated, at the axotomy site, with either a vehicle solution containing agarose or sucralfate, or acidic fibroblast growth factor (aFGF). Acidic FGF treatment increased the survival of the facial motoneurons from 18% to 70%. These results suggest that aFGF is a neurotrophic factor for motoneurons in vivo and that this growth factor may provide a new basis for the development of treatments to prevent the loss of damaged motoneurons. |
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Authors:
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P Cuevas; F Carceller; G Giménez-Gallego |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 197 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1996-02-22 Completed Date: 1996-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 183-6 Citation Subset: IM |
Affiliation:
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Servicio de Histología, Hospital Universitario Ramón y Cajal, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Axons / physiology* Cell Death / drug effects Denervation Facial Nerve / cytology, drug effects*, physiology Female Fibroblast Growth Factor 1 / pharmacology* Male Motor Neurons / drug effects*, physiology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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104781-85-3/Fibroblast Growth Factor 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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