Document Detail


Acid trehalase is involved in intracellular trehalose mobilization during postdiauxic growth and severe saline stress in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  19016884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of the acid trehalase encoded by the ATH1 gene in the yeast Saccharomyces cerevisiae is still unclear. In this work, we investigated the regulation of ATH1 transcription and found a clear involvement of the protein kinase Hog1p in the induction of this gene under severe stress conditions, such as high salt. We also detected changes in the acid trehalase activity and trehalose levels, indicating a role of the acid trehalase in intracellular trehalose mobilization. Finally, the growth analysis for different mutants in neutral and acid trehalases after high salt stress implicates acid trehalase activity in saline stress resistance.
Authors:
Elena Garre; Roberto Pérez-Torrado; José V Gimeno-Alcañiz; Emilia Matallana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-05
Journal Detail:
Title:  FEMS yeast research     Volume:  9     ISSN:  1567-1364     ISO Abbreviation:  FEMS Yeast Res.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-03-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101085384     Medline TA:  FEMS Yeast Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  52-62     Citation Subset:  IM    
Affiliation:
Departamento de Bioquímica y Biología Molecular, Universitat de València, Valencia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Gene Deletion
Gene Expression Profiling
Gene Expression Regulation, Fungal
Mitogen-Activated Protein Kinases / metabolism
Osmotic Pressure
Saccharomyces cerevisiae / enzymology*,  growth & development,  physiology
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Salinity
Transcription, Genetic
Trehalase / genetics,  metabolism*
Trehalose / metabolism*
Chemical
Reg. No./Substance:
0/Saccharomyces cerevisiae Proteins; 99-20-7/Trehalose; EC 2.7.10.-/HOG1 protein, S cerevisiae; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 3.2.1.28/ATH1 protein, S cerevisiae; EC 3.2.1.28/Trehalase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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