Document Detail


Acid stress upregulated outer membrane proteins in clinical isolates of Neisseria gonorrhoeae, but not most commensal Neisseria.
MedLine Citation:
PMID:  11683469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immune serum recognition of outer membrane components from commensal and pathogenic Neisseria cultured under neutral and acidic conditions was investigated. Acid stress caused no detectable alterations in lipooligosaccharide migration and (or) staining, in outer membrane protein profiles, or in immune serum recognition of outer membrane components from Neisseria mucosa or Neisseria sicca. There was also no difference in the lipoologosaccharide electrophoretic pattern of acid- and neutral-grown Neisseria lactamica, but there were differences in outer membrane protein expression. The outer membrane protein alterations induced by acid stress in N. lactamica were not the same as those seen in isolates from patients with uncomplicated gonococcal infection, pelvic inflammatory disease, and disseminated gonococcal infection. Many differences were detected in the immune serum recognition of outer membrane components from acid- and neutral-cultured N. lactamica and from the clinical isolates of Neisseria gonorrhoeae, and these should be considered in vaccine design.
Authors:
R K Pettit; T M Whelan; K S Woo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of microbiology     Volume:  47     ISSN:  0008-4166     ISO Abbreviation:  Can. J. Microbiol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2002-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372707     Medline TA:  Can J Microbiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  871-6     Citation Subset:  IM    
Affiliation:
Cancer Research Institute and Department of Microbiology, Arizona State University, Tempe 85287-2404, USA. pettitr@asu.edu
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MeSH Terms
Descriptor/Qualifier:
Bacterial Outer Membrane Proteins / analysis,  metabolism*
Culture Media
Gonorrhea / microbiology*
Humans
Hydrogen-Ion Concentration
Immunoblotting
Neisseria / metabolism*
Neisseria gonorrhoeae / metabolism*
Up-Regulation
Grant Support
ID/Acronym/Agency:
1R15AI35745-01/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Outer Membrane Proteins; 0/Culture Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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