Document Detail


Acid stimulated alkaline secretion in the rabbit duodenum is passive and correlates with mucosal damage.
MedLine Citation:
PMID:  3356358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low luminal acid concentrations stimulate alkaline secretion (AS) by the duodenal mucosa. We investigated acid stimulated alkaline secretion by proximal rabbit duodenal mucosa in an Ussing-chamber under different luminal acid concentrations and its relation to mucosal damage. Luminal alkalinisation and potential difference (PD) were measured and mucosal damage was investigated histologically. Luminal acid caused an increase of alkaline secretion over baseline (0.95 +/- 0.19 mu Eq/cm2/10 min; n = 55): 0.1 mmol: 7%, 1 mmol/l: 17%, 5 mmol/l: 22%, 10 mmol/l: 33%, 20 mmol/l: 34%, 50 mmol: 39%, 100 mmol/l: 27%. At acid concentrations of 10 mmol/l and above the PD fell from 2.0 +/- 1.0 mV to zero. Histology showed [H+]-dependent mucosal damage ranging from villus tip lesions to deep mucosal injury. Stimulation of alkaline secretion was not specific for acid. Ethanol (14%) stimulated alkaline secretion by 26%, and 28% ethanol by 40% over baseline. Ouabain and/or anoxia sensitive (active) alkaline secretion constituted 80% and 100% respectively of basal alkaline secretion. After exposure to various luminal acid concentrations passive diffusion (sensitive only to removal of nutrient HCO3-) was solely responsible for the rise in alkaline secretion. Only after 14% ethanol a small rise in ouabain and/or anoxia sensitive HCO3- transport was observed. Under the conditions of this study stimulation of duodenal alkaline secretion is not specific for luminal acid, but occurs also with luminal ethanol; both agents stimulate alkaline secretion depending on their concentration. In this model passive diffusion of HCO3- associated with increasing mucosal damage is the major component of the rise in alkaline secretion.
Authors:
P Vattay; W Feil; S Klimesch; E Wenzl; M Starlinger; R Schiessel
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Gut     Volume:  29     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  284-90     Citation Subset:  AIM; IM    
Affiliation:
University Clinic of Surgery I, Vienna General Hospital, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bicarbonates / secretion*
Biological Transport / drug effects
Diffusion
Duodenum / drug effects,  pathology,  secretion*
Ethanol / pharmacology
Female
Hydrochloric Acid / pharmacology*
Intestinal Mucosa / drug effects*,  pathology
Ouabain / pharmacology
Oxygen
Rabbits
Chemical
Reg. No./Substance:
0/Bicarbonates; 630-60-4/Ouabain; 64-17-5/Ethanol; 7647-01-0/Hydrochloric Acid; 7782-44-7/Oxygen
Comments/Corrections

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