| Acid sphingomyelinase in macrophage biology. | |
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MedLine Citation:
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PMID: 21533981 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Macrophages play a central role in innate immune responses, in disposal of cholesterol, and in tissue homeostasis and remodeling. To perform these vital functions macrophages display high endosomal/lysosomal activities. Recent studies have highlighted that acid sphingomyelinase (ASMase), which generates ceramide from sphingomyelin, is involved in modulation of membrane structures and signal transduction in addition to its metabolic role in the lysosome. In this review, we bring together studies on ASMase, its different forms and locations that are necessary for the macrophage to accomplish its diverse functions. We also address the importance of ASMase to several disease processes that are mediated by activated macrophages. |
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Authors:
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Jean-Philip Truman; Mohammed M Al Gadban; Kent J Smith; Samar M Hammad |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-2 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: - ISSN: 1420-9071 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 114 Doughty Street 629A, MSC 815, Charleston, SC, 29425, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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