| Acid sensing in renal epithelial cells. | |
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MedLine Citation:
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PMID: 15599393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney. |
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Authors:
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Stephen L Gluck |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 114 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-15 Completed Date: 2005-01-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 1696-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Nephrology, UCSF, 513 Parnassus Avenue, Box 0532, San Francisco, California 94143-0532, USA. glucks1@medicine.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cytosol / metabolism Enzyme Activation Epithelial Cells / metabolism* Focal Adhesion Kinase 2 Humans Hydrogen-Ion Concentration Kidney / cytology*, metabolism Kinetics Models, Biological Phosphorylation Protein Binding Protein Conformation Protein-Tyrosine Kinases / metabolism, physiology Sodium-Hydrogen Antiporter / chemistry src-Family Kinases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Sodium-Hydrogen Antiporter; 0/sodium-hydrogen exchanger 3; EC 2.7.10.1/Focal Adhesion Kinase 2; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/src-Family Kinases |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2004 Dec;114(12):1782-9
[PMID:
15599403
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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