Document Detail

Acid sensing in renal epithelial cells.
MedLine Citation:
PMID:  15599393     Owner:  NLM     Status:  MEDLINE    
The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.
Stephen L Gluck
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  114     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-15     Completed Date:  2005-01-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1696-9     Citation Subset:  AIM; IM    
Division of Nephrology, UCSF, 513 Parnassus Avenue, Box 0532, San Francisco, California 94143-0532, USA.
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MeSH Terms
Cell Line
Cytosol / metabolism
Enzyme Activation
Epithelial Cells / metabolism*
Focal Adhesion Kinase 2
Hydrogen-Ion Concentration
Kidney / cytology*,  metabolism
Models, Biological
Protein Binding
Protein Conformation
Protein-Tyrosine Kinases / metabolism,  physiology
Sodium-Hydrogen Antiporter / chemistry
src-Family Kinases / metabolism*
Reg. No./Substance:
0/Sodium-Hydrogen Antiporter; 0/sodium-hydrogen exchanger 3; EC Adhesion Kinase 2; EC Kinases; EC Kinases
Comment On:
J Clin Invest. 2004 Dec;114(12):1782-9   [PMID:  15599403 ]

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