Document Detail

An acid-sensing channel sows fear and panic.
MedLine Citation:
PMID:  19945375     Owner:  NLM     Status:  MEDLINE    
The amygdala is a brain region that coordinates fear responses to a variety of threats. Ziemann et al. (2009) now show that acid-sensing channels in the amygdala mediate fear responses that accompany inhalation of carbon dioxide, suggesting that aberrant chemosensation may underlie anxiety disorders associated with a fear of suffocation.
Stephen Maren
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  139     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2009-12-08     Revised Date:  2013-12-03    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  867-9     Citation Subset:  IM    
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MeSH Terms
Acid Sensing Ion Channels
Amygdala / metabolism*
Anxiety Disorders / metabolism*
Nerve Tissue Proteins / metabolism*
Sodium Channels / metabolism*
Grant Support
Reg. No./Substance:
0/Acid Sensing Ion Channels; 0/Nerve Tissue Proteins; 0/Sodium Channels
Comment On:
Cell. 2009 Nov 25;139(5):1012-21   [PMID:  19945383 ]

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