| Acid secretory responses and parietal cell sensitivity following duodenal ulcer healing with omeprazole, sucralfate, and Maalox. | |
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MedLine Citation:
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PMID: 1882910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acid secretory responses and parietal cell sensitivity (PCS) have been studied in 21 duodenal ulcer patients before and after successful treatment with omeprazole (n = 7), sucralfate (n = 7), or Maalox (n = 7). The second study was carried out 3 days after documented healing and withdrawal of treatment in the sucralfate- and Maalox-treated groups and 14 days after documented healing and withdrawal of treatment in the omeprazole-treated patients. Acid output (mmol/hour) was measured as basal secretion, and in response to 0.1 microgram/kg/hour pentagastrin (low-dose) and 6.0 micrograms/kg/hour pentagastrin (high-dose) stimulation. PCS was calculated as the ratio of low dose:high dose acid output (expressed as a percentage). Ulcer healing with sucralfate resulted in significant (p less than 0.05) decreases in low-dose acid output from 36.4% (13.2-51.0) (median [range]) to 8.4% (3.2-45.4) mmol/hour and PCS from 69.1% (44.9-91.4) to 22.0% (16.0-85.6), whereas no significant decreases in any of the measured parameters were noted following ulcer healing with Maalox. Ulcer healing with omeprazole resulted in significant (p less than 0.05) decreases in basal acid output from 6.3 (1.5-22.9) (median [range]) to 2.2 (0-6.9) mmol/hour, and low-dose acid output from 31.0 (6.0-58.0) to 23.0 (1.4-44.8) mmol/hour. These findings suggest that acid secretory responses following ulcer healing vary according to the therapeutic agent used. |
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Authors:
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D A Johnston; I N Marks; G O Young; N A Tigler-Wybrandi; S Bridger; J Zak |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of medicine Volume: 91 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-10-03 Completed Date: 1991-10-03 Revised Date: 2009-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 91S-94S Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Cape Town, Groote Schuur Hospital, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aluminum Hydroxide / pharmacology, therapeutic use* Antacids / pharmacology, therapeutic use* Drug Combinations Duodenal Ulcer / blood, diagnosis, drug therapy* Endoscopy, Gastrointestinal Fasting Female Gastric Acid / secretion* Gastric Acidity Determination Gastrins / blood Humans Magnesium Hydroxide / pharmacology, therapeutic use* Male Middle Aged Omeprazole / pharmacology, therapeutic use* Parietal Cells, Gastric / drug effects* Pentagastrin / diagnostic use Recurrence Sucralfate / pharmacology, therapeutic use* Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Drug Combinations; 0/Gastrins; 1309-42-8/Magnesium Hydroxide; 21645-51-2/Aluminum Hydroxide; 37317-08-1/aluminum hydroxide, magnesium hydroxide, drug combination; 54182-58-0/Sucralfate; 5534-95-2/Pentagastrin; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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