| Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. | |
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MedLine Citation:
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PMID: 15528910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge. |
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Authors:
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Y Iijima; F Cai; P Shen; G Walker; C Reynolds; E C Reynolds |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Caries research Volume: 38 ISSN: 0008-6568 ISO Abbreviation: Caries Res. Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2004-11-05 Completed Date: 2005-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0103374 Medline TA: Caries Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 551-6 Citation Subset: D; IM |
Copyright Information:
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2004 S. Karger AG, Basel. |
Affiliation:
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Department of Preventive Dentistry, School of Dentistry, Nagasaki University, Nagasaki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid
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pharmacology Adult Cariostatic Agents / therapeutic use* Caseins / therapeutic use* Chewing Gum* Cross-Over Studies Dental Enamel / drug effects* Double-Blind Method Female Humans Male Middle Aged Tooth Demineralization / therapy* Tooth Remineralization / methods* Xylitol |
| Chemical | |
Reg. No./Substance:
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0/Cariostatic Agents; 0/Caseins; 0/Chewing Gum; 0/casein phosphopeptide-amorphous calcium phosphate nanocomplex; 64-19-7/Acetic Acid; 87-99-0/Xylitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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