| Acid phosphatase stimulation of the growth of Nocardia asteroides and its possible relationship to the modification of lysosomal enzymes in macrophages. | |
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MedLine Citation:
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PMID: 3286504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lysosomal acid phosphatase levels are reduced in murine macrophages by virulent strains of Nocardia asteroides. At the same time, other lysosomal enzymes either remain unchanged or increase in activity, indicating that acid phosphatase is not lost because of degranulation or membrane leakage. This study shows that acid phosphatase was utilized as a sole carbon source by Nocardia asteroides and that acid phosphatase combined with glutamate as a carbon source enhanced nocardial growth. As a consequence, the inverse relationship that was observed between acid phosphatase activity and the bactericidal capacity of macrophages infected with N. asteroides appears to be due to the ability of N. asteroides to preferentially metabolize this lysosomal enzyme during growth within phagocytes. |
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Authors:
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L Beaman; M Paliescheskey; B L Beaman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Infection and immunity Volume: 56 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-06-30 Completed Date: 1988-06-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1652-4 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis 95616. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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physiology* Animals Lysosomes / enzymology*, microbiology Macrophages / enzymology*, microbiology Mice Nocardia asteroides / growth & development*, pathogenicity Virulence |
| Grant Support | |
ID/Acronym/Agency:
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1R01-AI-20900/AI/NIAID NIH HHS; AI-19579/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.2/Acid Phosphatase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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