Document Detail

Acid perfusion of duodenal ulcer craters and ulcer pain: a controlled double blind study.
MedLine Citation:
PMID:  3732901     Owner:  NLM     Status:  MEDLINE    
Although early studies attributed an important role to acid in the pathogenesis of duodenal ulcer pain, recent reports are conflicting. The aim of the present study is to determine whether direct acidification of the duodenal ulcer crater in symptomatic patients reproduces ucler pain. Patients with endoscopically diagnosed duodenal ulcers were studied. No premedication or sedation was given. A washing tube was passed via the endoscope and 0.1 N hydrochloric acid as well as normal saline were sequentially administered on to the ulcer crater, the sequence of infusion being randomised and double blind. Forty patients were studied. Sixteen developed typical ulcer pain during acid infusion compared with four with saline (p less than 0.005). Ten patients who developed pain on acid were rechallenged with acid after their pains disappeared. Typical pain recurred in all. Twenty patients without duodenal ulcer did not develop pain when 200 ml of 0.1 N hydrochloric acid was infused into the duodenum. Acid therefore appears to have a definite role in the pathogenesis of duodenal ulcer pain although other factors may also be important.
J Y Kang; I Yap; R Guan; H H Tay
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gut     Volume:  27     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-25     Completed Date:  1986-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  942-5     Citation Subset:  AIM; IM    
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MeSH Terms
Double-Blind Method
Duodenal Ulcer / physiopathology*
Hydrochloric Acid / diagnostic use*
Middle Aged
Pain / etiology,  physiopathology*
Reg. No./Substance:
7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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