Document Detail


Acid mucopolysaccharides of chick-embryo cartilage in osteolathyrism.
MedLine Citation:
PMID:  4226014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. In view of the suggested association between collagen and acid mucopolysaccharides in the connective tissues, this study was designed to see whether the lathyrus factor, beta-aminopropionitrile, affected the acid mucopolysaccharides as well as inhibiting the normal polymerization of collagen. The changing pattern of these two components of cartilage from normal and lathyritic chick embryos aged 14-20 days is described. The chondroitin sulphates and their protein complexes have been isolated from these cartilages, characterized and compared, particularly with respect to their sulphate content; no significant differences in quality or quantity were detectable. 2. Saline extracts of normal and lathyritic cartilages were also compared; whereas the collagen content of lathyritic extracts was increased to ten times that in the normal, the acid mucopolysaccharide content of both extracts was always the same. 3. It therefore appears that in the chick embryo beta-aminopropionitrile does not affect the acid mucopolysaccharides of the developing cartilage.
Authors:
C I Levene; J Kranzler; S Franco-Browder
Related Documents :
6849974 - The glycosaminoglycans of pig colonic wall connective tissue.
563284 - Urinary glycosaminoglycan patterns in angiosarcoma of the liver.
1201754 - Changes in guinea-pig dermal collagen during development.
8033894 - Analysis of heparan-sulphate chains and oligosaccharides from proliferating and quiesce...
23852864 - Benzoyl-coa pathway-mediated metabolism of meta-hydroxy-aromatic acids in rhodopseudomo...
6547054 - Inhibition of carboxypeptidase a by aldehyde and ketone substrate analogues.
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  101     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1966 Nov 
Date Detail:
Created Date:  1967-08-03     Completed Date:  1967-08-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  435-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis
Aminopropionitrile
Animals
Bone Diseases / metabolism*
Cartilage / analysis*,  embryology
Chick Embryo
Collagen / analysis
Cyanides*
Glycosaminoglycans / metabolism*
Hexosamines / analysis
Lathyrism / chemically induced*,  metabolism*
Nitrogen / analysis
Sulfates / analysis
Uronic Acids / analysis
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Cyanides; 0/Glycosaminoglycans; 0/Hexosamines; 0/Sulfates; 0/Uronic Acids; 151-18-8/Aminopropionitrile; 7727-37-9/Nitrogen; 9007-34-5/Collagen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Studies of lung metabolism. I. Isolation and properties of subcellular fractions from rabbit lung.
Next Document:  Enzyme transfer of phosphate from adenosine triphosphate to protein-bound serine residues in cerebra...