Document Detail

Acid mucopolysaccharides of chick-embryo cartilage in osteolathyrism.
MedLine Citation:
PMID:  4226014     Owner:  NLM     Status:  MEDLINE    
1. In view of the suggested association between collagen and acid mucopolysaccharides in the connective tissues, this study was designed to see whether the lathyrus factor, beta-aminopropionitrile, affected the acid mucopolysaccharides as well as inhibiting the normal polymerization of collagen. The changing pattern of these two components of cartilage from normal and lathyritic chick embryos aged 14-20 days is described. The chondroitin sulphates and their protein complexes have been isolated from these cartilages, characterized and compared, particularly with respect to their sulphate content; no significant differences in quality or quantity were detectable. 2. Saline extracts of normal and lathyritic cartilages were also compared; whereas the collagen content of lathyritic extracts was increased to ten times that in the normal, the acid mucopolysaccharide content of both extracts was always the same. 3. It therefore appears that in the chick embryo beta-aminopropionitrile does not affect the acid mucopolysaccharides of the developing cartilage.
C I Levene; J Kranzler; S Franco-Browder
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  101     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1966 Nov 
Date Detail:
Created Date:  1967-08-03     Completed Date:  1967-08-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  435-40     Citation Subset:  IM    
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MeSH Terms
Amino Acids / analysis
Bone Diseases / metabolism*
Cartilage / analysis*,  embryology
Chick Embryo
Collagen / analysis
Glycosaminoglycans / metabolism*
Hexosamines / analysis
Lathyrism / chemically induced*,  metabolism*
Nitrogen / analysis
Sulfates / analysis
Uronic Acids / analysis
Reg. No./Substance:
0/Amino Acids; 0/Cyanides; 0/Glycosaminoglycans; 0/Hexosamines; 0/Sulfates; 0/Uronic Acids; 151-18-8/Aminopropionitrile; 7727-37-9/Nitrogen; 9007-34-5/Collagen

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