| Acid mucins in human intestinal goblet cells. | |
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MedLine Citation:
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PMID: 748514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acid mucins in goblet cells of the duodenum, jejunum and ileum of neonates and infants with cystic fibrosis (CF) and without CF were measured by scanning microdensitometry after alcian blue staining according to the protocol of McCarthy and Reid (1963) which characterises four groups of acidic mucins. In CF infants over 6 mth of age, but not in controls, there was an increase along the gut from duodenum to ileum of both weakly acidic and strongly acidic sulphomucins. In the ileum the increase was in total mucins from 6 mth previously in the same CF patients and this difference could be accounted for by an increase of sialidase-resistant mucins. The increase in sulphomucins was more marked at the tip than at the base of the villi. In CF neonates there was significant difference in the quantities of acidic mucins. The question whether the mucins of CF are chemically abnormal or merely accumulated to an abnormal extent is probably best investigated by analysis of sialidase-resistant mucins and sulphomucins of the ileum and strongly acidic sulphomucins of the duodenum and jejunum in CF infants over 6 mth of age. |
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Authors:
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S M Morrissey; M C Tymvios |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pathology Volume: 126 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-06-29 Completed Date: 1979-06-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 197-208 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Count Cystic Fibrosis / metabolism*, pathology Duodenum / metabolism Histocytochemistry Humans Ileum / metabolism Infant Infant, Newborn Infant, Newborn, Diseases / metabolism*, pathology Intestine, Small / metabolism*, pathology Jejunum / metabolism Mucins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Mucins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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