| Acid-labile anchoring linkages for solid phase synthesis of C-terminal asparagine peptides using the Fmoc strategy. | |
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MedLine Citation:
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PMID: 2272754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two acid-labile substituted benzylamine type anchoring linkages, 4-benzoxy-2,6-dimethoxybenzylamine and 2-benzoxy-4,6-dimethoxybenzylamine, for solid phase synthesis of peptide amides were prepared. The Na-9-fluorenylmethyloxycarbonyl (Fmoc) amino acids could be easily attached to the resins with DCC/HOBt (loading 0.5-0.6 mmol/g resin). After final removal of the Na-protecting groups, treatment with TFA (50-95%) yielded amino acid and peptide amides in high purity. As we could show for the synthesis of thymulin (FTS, pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn), these two resins with anchoring linkages are well suited for the synthesis of C-terminal Asn peptides using protected aspartic acid derivative as starting material. |
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Authors:
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J Shao; Y H Li; W Voelter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of peptide and protein research Volume: 36 ISSN: 0367-8377 ISO Abbreviation: Int. J. Pept. Protein Res. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1991-02-28 Completed Date: 1991-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330420 Medline TA: Int J Pept Protein Res Country: DENMARK |
Other Details:
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Languages: eng Pagination: 182-7 Citation Subset: IM |
Affiliation:
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Department of Physical Biochemistry, University of Tübingen, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Amino Acids* Asparagine Fluorenes* Indicators and Reagents* Molecular Sequence Data Peptides / chemical synthesis* Resins, Synthetic / chemical synthesis* Thymic Factor, Circulating / chemical synthesis |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Fluorenes; 0/Indicators and Reagents; 0/N(alpha)-fluorenylmethyloxycarbonylamino acids; 0/Peptides; 0/Resins, Synthetic; 7006-34-0/Asparagine; 78922-62-0/Thymic Factor, Circulating |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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