| Acid-initiated polymerization of epsilon-caprolactone under microwave irradiation and its application in the preparation of drug controlled release system. | |
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MedLine Citation:
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PMID: 12713097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acid-initiated ring-opening polymerization (ROP) of epsilon-caprolactone (epsilon-CL) was conducted under microwave irradiation (MI) at 2.45 GHz. At this frequency, metallic catalysts were no longer necessary. The effects of microwave power, irradiation time, epsilon-CL: acid molar ratio and acidity of acid on the polymerization were investigated. Both the rate of polymerization and the molar mass of polymer obtained were enhanced in comparison with conventional thermal method. Poly(epsilon-caprolactone) (PCL) with weight-average molar mass (Mw) over 12000 g/mol and Mw/Mn below 1.6 was synthesized in the presence of carboxylic acids such as maleic acid (MA), succinic acid (SA) and adipic acid (AA). The polymerization was also carried out when the monomer contained a certain amount of ibuprofen (IBU), by which, the IBU-PCL controlled release system was prepared directly. The release of IBU from the system was sustained from 12 h to 9 days with IBU content in weight increasing from 5 to 20%. It seems that this is a promising method to prepare drug controlled release systems. |
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Authors:
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Ying Song; Lijian Liu; Xiaocheng Weng; Renxi Zhuo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomaterials science. Polymer edition Volume: 14 ISSN: 0920-5063 ISO Abbreviation: J Biomater Sci Polym Ed Publication Date: 2003 |
Date Detail:
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Created Date: 2003-04-25 Completed Date: 2003-12-04 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 9007393 Medline TA: J Biomater Sci Polym Ed Country: Netherlands |
Other Details:
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Languages: eng Pagination: 241-53 Citation Subset: IM |
Affiliation:
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Department of Polymer Science, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, P. R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials Delayed-Action Preparations* Hexanoic Acids / chemistry*, radiation effects* Lactones / chemistry*, radiation effects* Magnetic Resonance Spectroscopy Microwaves* Molecular Structure Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Delayed-Action Preparations; 0/Hexanoic Acids; 0/Lactones; 502-44-3/caprolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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