Document Detail


Acid glycosaminoglycans in experimental pleural effusions.
MedLine Citation:
PMID:  3114570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acid glycosaminoglycans (GAG) were quantitated and partially characterized in pleural effusions in guinea pigs with experimental allergic pleurisy. Increase of GAG in the pleural effusion preceded the increase of effusion volume. Effusion was associated with the presence of cuboidal mesothelial cells on visceral pleura, and hemorrhage, infiltration of neutrophils, and destruction of the alveolar structure of the lung. A significant difference was found in the relative percentage of GAG subtypes in the effusion, serum, and the lung tissue of guinea pigs with experimental pleurisy. There was a difference in molecular size of hyaluronic acid in pleural effusion between the early and late stages of pleurisy. Presumably GAGs found in pleural effusion were released from the pleural tissue.
Authors:
K Satoh; H Arai; H Nagai; M Ito; H Sato; M Motomiya; K Konno
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lung     Volume:  165     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Glycosaminoglycans / classification,  metabolism*
Guinea Pigs
Lung / pathology
Male
Neutrophils / pathology
Pleura / pathology
Pleural Effusion / complications,  metabolism*,  pathology
Pleurisy / complications
Chemical
Reg. No./Substance:
0/Glycosaminoglycans

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