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Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery.
MedLine Citation:
PMID:  21113530     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.
Authors:
Kyle E Broaders; Stefan J Pastine; Sirisha Grandhe; Jean M J Fréchet
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-11-26
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  47     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  665-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, UC Berkeley, Berkeley, CA, USA.
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