Document Detail


Acid-degradable polymers for drug delivery: a decade of innovation.
MedLine Citation:
PMID:  23320254     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polymers that start degrading under acidic conditions are increasingly investigated as a pathway to trigger the release of drugs once the drug carrier reached the slightly acidic tumour environment or after the drug carrier has been taken up by cells, resulting in the localization of the polymer in the acidic endosomes and lysosomes. The advances in the design of acid-degradable polymers and drug delivery systems have been summarized and discussed in this review article. Various acid-labile groups such as acetals, orthoester, hydrazones, imines and cis-aconityl, that can undergo cleavage in slightly acidic conditions, have been employed to create polymer architectures or polymer-drug conjugates that can degrade under lysosomal and endosomal conditions, triggering the fast release of drugs or DNA.
Authors:
Sandra Binauld; Martina H Stenzel
Related Documents :
17598544 - An alternative sampling technique for cucumber beetles (coleoptera: chrysomelidae) and ...
2866634 - Disposition of the psychotropic drugs buspirone, mj-13805 and piribedil, and of their c...
2313004 - Psychotropic drug use among caregivers of patients with dementia.
419164 - Hzi systems for eeg parametrization and classification of psychotropic drugs.
7263204 - Fatal aplastic anemia due to indomethacin--lymphocyte transformation tests in vitro.
8864794 - Zidovudine glucuronidation in human liver: interindividual variability.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centre for Advanced Macromolecular Design, (CAMD), The University of New South Wales, Sydney NSW 2052, Australia. m.stenzel@unsw.edu.au.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Copper deficiency in sheep with high liver iron accumulation.
Next Document:  Shape-persistent H-bonded macrocyclic aromatic pentamers.