Document Detail


THE ACID-BASE STATUS IN CYANOTIC CONGENITAL HEART DISEASE.
MedLine Citation:
PMID:  14285299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relation between oxygen consumption, metabolic status and prognosis was studied in two infants with identically low arterial oxygen tensions (20 mm. Hg) due to cyanotic congenital heart disease. The first patient had low oxygen consumption, arterial blood acidosis and increased arterial lactate, and died at the age of 36 hours. The second had normal oxygen consumption, arterial acid-base balance, lactate and pyruvate, and survived. Since arterial oxygen tensions were similar in both, it was concluded that compensatory factors, such as cardiac output, pulmonary and systemic blood flow and increased oxygen saturation at normal pH levels (Bohr effect), are important in maintaining tissue oxidation and preventing anaerobiosis and lactate production. The importance of a knowledge of acid-base status in the immediate prognosis of cyanotic congenital heart disease is stressed. The treatment of acidosis by buffer therapy may be an important palliative, improving cardiac output and tissue oxidation, and should be undertaken as soon as possible before irreversible cellular damage has occurred.
Authors:
H LEVISON; P R SWYER
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Medical Association journal     Volume:  92     ISSN:  0008-4409     ISO Abbreviation:  Can Med Assoc J     Publication Date:  1965 May 
Date Detail:
Created Date:  1965-08-01     Completed Date:  1996-12-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0414110     Medline TA:  Can Med Assoc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1127-9     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium*
Acidosis*
Heart Defects, Congenital*
Infant, Newborn*
Lactates*
Metabolism*
Prognosis*
Pyruvates*
Chemical
Reg. No./Substance:
0/Lactates; 0/Pyruvates
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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