| THE ACID-BASE STATUS IN CYANOTIC CONGENITAL HEART DISEASE. | |
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MedLine Citation:
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PMID: 14285299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relation between oxygen consumption, metabolic status and prognosis was studied in two infants with identically low arterial oxygen tensions (20 mm. Hg) due to cyanotic congenital heart disease. The first patient had low oxygen consumption, arterial blood acidosis and increased arterial lactate, and died at the age of 36 hours. The second had normal oxygen consumption, arterial acid-base balance, lactate and pyruvate, and survived. Since arterial oxygen tensions were similar in both, it was concluded that compensatory factors, such as cardiac output, pulmonary and systemic blood flow and increased oxygen saturation at normal pH levels (Bohr effect), are important in maintaining tissue oxidation and preventing anaerobiosis and lactate production. The importance of a knowledge of acid-base status in the immediate prognosis of cyanotic congenital heart disease is stressed. The treatment of acidosis by buffer therapy may be an important palliative, improving cardiac output and tissue oxidation, and should be undertaken as soon as possible before irreversible cellular damage has occurred. |
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Authors:
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H LEVISON; P R SWYER |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian Medical Association journal Volume: 92 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1965 May |
Date Detail:
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Created Date: 1965-08-01 Completed Date: 1996-12-01 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
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Languages: eng Pagination: 1127-9 Citation Subset: OM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium* Acidosis* Heart Defects, Congenital* Infant, Newborn* Lactates* Metabolism* Prognosis* Pyruvates* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Pyruvates |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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