Document Detail


Acid-base status at birth and subsequent neurosensory impairment in surviving 500 to 1000 gm infants.
MedLine Citation:
PMID:  8296844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to assess, in infants born weighing < or = 1000 gm, if umbilical cord blood acid-base measures at birth are associated with an additional increase in neurosensory impairment. STUDY DESIGN: Of 289 surviving infants with a birth weight of 500 to 1000 gm born from 1979 to 1989, 219 had umbilical cord acid-base status measured at birth and were followed prospectively for > or = 1 year. Measures of neurologic impairment used in this study included mental retardation, cerebral palsy, and major neurosensory impairment. RESULTS: Gestational age was inversely associated with all neurosensory impairments and was a better predictor of subsequent impairment in this population than was birth weight. Very low umbilical cord pH values were also significantly related to adverse outcomes. There was also an inverse relationship between cord blood bicarbonate levels and major neurosensory impairment. The highly significant relationship between cord blood bicarbonate and pH values and the development of neurosensory impairments persisted in spite of adjustment for gestational age, birth weight, plurality, use of general anesthesia, maternal race, and presence of hypertension. CONCLUSION: An adverse acid-base status at birth is additive to the effect of gestational age in predicting neurosensory impairment in infants weighing < or = 1000 gm.
Authors:
F L Gaudier; R L Goldenberg; K G Nelson; M Peralta-Carcelen; S E Johnson; M B DuBard; T Y Roth; J C Hauth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  170     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-03-01     Completed Date:  1994-03-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Alabama at Birmingham.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium*
Bicarbonates / blood
Birth Weight
Blood Gas Analysis
Cerebral Palsy / epidemiology
Chi-Square Distribution
Fetal Blood / chemistry*
Follow-Up Studies
Gestational Age
Humans
Hydrogen-Ion Concentration
Incidence
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature, Diseases / blood,  epidemiology*
Mental Retardation / epidemiology
Nervous System Diseases / blood,  epidemiology*
Odds Ratio
Prospective Studies
Grant Support
ID/Acronym/Agency:
282-92-0055//PHS HHS
Chemical
Reg. No./Substance:
0/Bicarbonates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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