Document Detail

Acid-base significance of meconium discovered prior to labor.
MedLine Citation:
PMID:  8476478     Owner:  NLM     Status:  MEDLINE    
Although the significance of meconium in the amniotic fluid diagnosed during labor remains problematic, there is little information regarding the significance of meconium discovered prior to labor. The present study consisted of 40 term pregnancies with meconium found at amniocentesis for lung maturity (n = 7) or elective cesarean section (n = 33) and 40 uncomplicated, control pregnancies with clear amniotic fluid at elective cesarean section. The mean umbilical artery (UA) blood pH was 7.26 in the meconium group and 7.28 in the control group. Overall, the frequency of fetal acidemia (UA pH < 7.20) was 15% (6 of 40) of the infants in the meconium group versus 8% (3 of 40) in the control group (p = 0.24). All nine of these infants had a respiratory acidosis defined as a UA blood pH less than 7.20 with normal bicarbonate and elevated carbon dioxide pressure. Importantly, none of the neonates had metabolic acidemia and all had uncomplicated hospital courses. All of the pregnancies reported were promptly delivered because of meconium and we therefore cannot recommend nonintervention when meconium is diagnosed in the antepartum period. Meconium discovered prior to labor is not necessarily a marker of immediate or chronic fetal compromise.
S M Ramin; L C Gilstrap; K J Leveno; J S Dax; B B Little
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  10     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-24     Completed Date:  1993-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032.
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MeSH Terms
Acid-Base Equilibrium*
Acidosis / blood,  diagnosis
Acidosis, Respiratory / blood,  diagnosis
Amniotic Fluid / chemistry
Case-Control Studies
Fetal Blood / chemistry
Hydrogen-Ion Concentration
Infant, Newborn
Labor, Obstetric*
Meconium / chemistry*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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