Document Detail

Acid-base regulation of angiotensin receptors in the kidney.
MedLine Citation:
PMID:  19816174     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Angiotensin II (Ang II) is a major systemic regulator of blood pressure, blood volume, and acid-base homeostasis. However, the effects of local Ang II signaling in the kidney are less well known. Here we review the impact of Ang II on acid-base transport in specific nephron segments and discuss the recently described role of acid loading in sensitizing the proximal tubule to Ang II.
RECENT FINDINGS: Recent studies suggest that Ang II signaling is necessary for a normal kidney response to acid loads. Under acidic conditions, tubule cells upregulate type 1 Ang II receptors, amplifying the effects of Ang II. Site of action may also affect Ang II activity, as Ang II can produce divergent effects when acting on the luminal versus basolateral aspects of tubule cells. High luminal concentrations of Ang II and its precursors may facilitate coordinated acid-base transport and metabolic activity throughout the nephron.
SUMMARY: Local Ang II signaling in the kidney directly modulates acid-base transport and metabolism, providing an additional mechanism by which the renin-angiotensin-aldosterone system regulates acid-base balance. The segment-specific and acid-stimulated responses of the tubule to Ang II are diverse and merit further exploration for their adaptive and potentially maladaptive roles.
Glenn T Nagami; Jeffrey A Kraut
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  19     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-03-04     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
Nephrology Section and Nephrology Research Laboratory, Department of Medicine and Research Service, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA.
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MeSH Terms
Acid-Base Equilibrium / drug effects,  physiology*
Angiotensin II / pharmacology,  physiology
Kidney / drug effects,  physiology*
Models, Biological
RNA, Messenger / genetics,  metabolism
Receptor, Angiotensin, Type 1 / genetics,  physiology
Receptors, Angiotensin / physiology*
Signal Transduction
Reg. No./Substance:
0/RNA, Messenger; 0/Receptor, Angiotensin, Type 1; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II

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