Document Detail

Acid-base properties of selected flavonoid glycosides.
MedLine Citation:
PMID:  15911223     Owner:  NLM     Status:  MEDLINE    
Naringin dissociation constants were determined by analytical methods. Dissociation reactions of naringin and rutin were modelled with AM1 quantum chemistry method. The analysis of physicochemical parameters achieved by AM1 method allowed for determination of acid-base properties of hydroxyl group of flavonoid glycosides studied. The sequence in which hydrogen atoms dissociate from hydroxyl groups in flavonoid glycosides is 7-OH>4'-OH>3'-OH>5-OH. The analysis of selection of descriptors essential for further studies aiming at elucidation of relationship between acidity of hydroxyl groups and their biological effect was performed.
Cecylia Mielczarek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-07
Journal Detail:
Title:  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences     Volume:  25     ISSN:  0928-0987     ISO Abbreviation:  Eur J Pharm Sci     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-24     Completed Date:  2005-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9317982     Medline TA:  Eur J Pharm Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Department of Analytical Chemistry, Chair of Medical Chemistry, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego Str. 1, Łódź 90-151, Poland.
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MeSH Terms
Flavanones / chemistry*
Glycosides / chemistry*
Hydrogen-Ion Concentration
Models, Chemical
Rutin / chemistry*
Reg. No./Substance:
0/Flavanones; 0/Glycosides; 10236-47-2/naringin; 153-18-4/Rutin

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