| Acid-base metabolism: implications for kidney stones formation. | |
| | |
MedLine Citation:
|
PMID: 16411127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The physiology and pathophysiology of renal H+ ion excretion and urinary buffer systems are reviewed. The main focus is on the two major conditions related to acid-base metabolism that cause kidney stone formation, i.e., distal renal tubular acidosis (dRTA) and abnormally low urine pH with subsequent uric acid stone formation. Both the entities can be seen on the background of disturbances of the major urinary buffer system, NH3+ <--> NH4+. On the one hand, reduced distal tubular secretion of H+ ions results in an abnormally high urinary pH and either incomplete or complete dRTA. On the other hand, reduced production/availability of NH4+ is the cause of an abnormally low urinary pH, which predisposes to uric acid stone formation. Most recent research indicates that the latter abnormality may be a renal manifestation of the increasingly prevalent metabolic syndrome. Despite opposite deviations from normal urinary pH values, both the dRTA and uric acid stone formation due to low urinary pH require the same treatment, i.e., alkali. In the dRTA, alkali is needed for improving the body's buffer capacity, whereas the goal of alkali treatment in uric acid stone formers is to increase the urinary pH to 6.2-6.8 in order to minimize uric acid crystallization. |
| | |
Authors:
|
Bernhard Hess |
Related Documents
:
|
12429297 - Biochemical distinction between hyperuricosuric calcium urolithiasis and gouty diathesis. 3711797 - Haemolysis as an interference factor in clinical chemistry. 18968307 - Direct determination of uric acid in serum by a fluorometric-enzymatic method based on ... 2038747 - Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. ii. competit... 21447017 - Resuscitation of escherichia coli vbnc cells depends on a variety of environmental or c... 3207747 - Mechanisms of interaction of amino acids with phospholipid bilayers during freezing. |
Publication Detail:
|
Type: Journal Article; Review Date: 2006-01-13 |
Journal Detail:
|
Title: Urological research Volume: 34 ISSN: 0300-5623 ISO Abbreviation: Urol. Res. Publication Date: 2006 Apr |
Date Detail:
|
Created Date: 2006-03-23 Completed Date: 2006-12-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0364311 Medline TA: Urol Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 134-8 Citation Subset: IM |
Affiliation:
|
Internal Medicine and Nephrology, Klinik Im Park, Bellariastrasse 38, 8038, Zurich, Switzerland. bernhard.hess@hirslanden.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acidosis, Renal Tubular
/
etiology,
metabolism Acids / chemistry, metabolism* Alkalies / chemistry, metabolism* Bicarbonates / metabolism Humans Hydrogen-Ion Concentration Kidney Calculi / etiology*, metabolism Urine / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Acids; 0/Alkalies; 0/Bicarbonates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clusterin induces differentiation of pancreatic duct cells into insulin-secreting cells.
Next Document: Direct comparison between genomic constitution and flavonoid contents in Allium multiple alien addit...