| Acid-base induced alterations in glutamine metabolism and ureogenesis in perfused muscle and liver of the rat. | |
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MedLine Citation:
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PMID: 411675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of altered acid-base balance on the production of urea and the metabolism of glutamine were investigated in the isolated perfused liver and hindquarter of the rat. In the isolated perfused rat liver, lowering of perfusate pH without altering bicarbonate concentration significantly reduced urea production and increased net glutamine synthesis, although the converse did not obtain. In the isolated perfused rat hindquarter when perfusate pH and bicarbonate were simultaneously reduced glutamine synthesis was significantly increased. The combined hepatic and muscle increase in glutamine synthesis accounted for 89% of the decrease in hepatic urea synthesis under these experimental conditions. These changes in nitrogen metabolism are interpreted in terms of adaptations which offset the initial alterations in hydrogen ion homeostasis. |
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Authors:
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J Oliver; A M Koelz; J Costello; E Bourke |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 7 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 445-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Imbalance
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metabolism* Animals Female Glutamine / metabolism* Liver / metabolism* Male Muscles / metabolism* Perfusion Rats Urea / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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56-85-9/Glutamine; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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