Document Detail

Acid-base, electrolyte and metabolite concentrations in packed red blood cells for major transfusion in infants.
MedLine Citation:
PMID:  11240874     Owner:  NLM     Status:  MEDLINE    
METHODS: Acid-base, electrolyte and metabolite concentrations were determined in 100 U of packed red blood cells (RBC) preserved in extended-storage media to be used for major transfusion in paediatric and cardiac surgery. RESULTS: In fresh RBC, low pH, bicarbonate (cHCO3-), base excess (BE) and high glucose values were observed all outside the physiological range. With lengthening storage duration, values of pH, cHCO3-, BE, sodium and glucose decreased and carbon dioxide, potassium and lactic acid concentrations increased [mean +/- SD (range): storage duration 6.7 +/- 3.8 (1-17) days, pH 6.79 +/- 0.1 (6.53-6.99); mmol.l-1: cHCO3- 11.1 +/- 1.5 (6.2-14.5), BE - 29.2 +/- 4.1 ([-39.4] - [-20.9]), potassium 20.5 +/- 7.8 (4.2-43.6), glucose 24.1 +/- 6.1 (16.7-29.2), lactic acid 9.4 +/- 4 (4.3-21.4)]. CONCLUSION: Massive and rapid transfusion of RBC may lead to a severe burden of hydrogen ions, carbon dioxide, potassium, glucose and lactic acid and this can be avoided by cell saver blood processing, when autologous erythrocytes from the operative field are saved and substrate load and storage lesions from packed red blood cells are minimized in one step by washing.
R Sümpelmann; T Schürholz; E Thorns; J Hausdörfer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  11     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Anästhesie III, OE 8060, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.
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MeSH Terms
Acid-Base Equilibrium*
Bicarbonates / blood
Blood Glucose / analysis
Blood Preservation*
Carbon Dioxide / blood
Electrolytes / blood*
Erythrocyte Transfusion* / adverse effects
Erythrocytes / chemistry*
Hydrogen-Ion Concentration
Lactic Acid / blood
Potassium / blood
Sodium / blood
Reg. No./Substance:
0/Bicarbonates; 0/Blood Glucose; 0/Electrolytes; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7440-09-7/Potassium; 7440-23-5/Sodium

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