Document Detail

Acid-base disturbances in the intensive care unit: current issues and the use of continuous renal replacement therapy as a customized treatment tool.
MedLine Citation:
PMID:  18286450     Owner:  NLM     Status:  MEDLINE    
Continuous renal replacement therapies (CRRT) are often used to manage complex acid-base problems in critically ill patients. These techniques allow a constant manipulation of the plasma composition. Several technical factors from CRRT influence the acid-base status; namely, the effluent rate, the operational characteristics of the technique, the content of the solutions and the metabolic rate of the buffer. This article reviews the common acid base disorders occurring in the intensive care unit, using both the anion gap and the strong ion gap approaches, and describes the influence of CRRT on acid-base physiology. The use of CRRT as a customized therapy for acid-base disorders is discussed, allowing an integration of both physiological and technical concepts.
J Bouchard; R L Mehta
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  31     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  6-14     Citation Subset:  IM    
Division of Nephrology, Department of Medicine, University of California San Diego, California - USA.
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MeSH Terms
Acid-Base Equilibrium / drug effects,  physiology*
Acidosis / drug therapy,  physiopathology
Alkalosis / drug therapy,  physiopathology
Dialysis Solutions / chemistry,  pharmacology
Hemofiltration / methods*
Intensive Care Units
Kidney / injuries
Kidney Failure, Acute / therapy*
Reg. No./Substance:
0/Dialysis Solutions

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