Document Detail

Acid-base conditions regulate calcium and magnesium homeostasis.
MedLine Citation:
PMID:  20228004     Owner:  NLM     Status:  In-Process    
BACKGROUND: Previous experimental studies demonstrate that the acid-base balance influences mineral homeostasis by regulating the absorption of calcium and magnesium in the kidneys. No intervention studies are available on population samples. AIMS: To study the urinary excretion of calcium and magnesium before and after an intervention with the aim of decreasing the acid load. METHODS: Healthy subjects aged 50-75 years were recruited by advertising. Urinary calcium, magnesium and urea as well as blood pressure were measured before and after the intervention. This comprised taking tablets containing potassium hydrogen carbonate or potassium chloride (placebo) during 7-10 days. RESULTS: There were significant relationships between the urinary excretion of urea and magnesium and calcium before the intervention. Comparing before and after intervention, the change in urinary excretion of urea was related to a change in urinary excretion of calcium and magnesium. There was a significant decrease in systolic as well as diastolic blood pressure both after administration of potassium hydrogen carbonate and citrate. CONCLUSION: The results confirm previous studies showing a relation between acid conditions in the body and the excretion of calcium and add new data on magnesium. A blood pressure decrease after potassium has been found in previous studies. This suggests an alternative for the treatment of moderately increased levels of blood pressure that should be further explored.
Ragnar Rylander; Tommi Tallheden; Jürgen Vormann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnesium research : official organ of the International Society for the Development of Research on Magnesium     Volume:  22     ISSN:  0953-1424     ISO Abbreviation:  Magnes Res     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-03-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900948     Medline TA:  Magnes Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  262-5     Citation Subset:  IM    
BioFact Environmental Health Research Center, Lerum, Sweden.
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