| Acid-base conditions regulate calcium and magnesium homeostasis. | |
| | |
MedLine Citation:
|
PMID: 20228004 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Previous experimental studies demonstrate that the acid-base balance influences mineral homeostasis by regulating the absorption of calcium and magnesium in the kidneys. No intervention studies are available on population samples. AIMS: To study the urinary excretion of calcium and magnesium before and after an intervention with the aim of decreasing the acid load. METHODS: Healthy subjects aged 50-75 years were recruited by advertising. Urinary calcium, magnesium and urea as well as blood pressure were measured before and after the intervention. This comprised taking tablets containing potassium hydrogen carbonate or potassium chloride (placebo) during 7-10 days. RESULTS: There were significant relationships between the urinary excretion of urea and magnesium and calcium before the intervention. Comparing before and after intervention, the change in urinary excretion of urea was related to a change in urinary excretion of calcium and magnesium. There was a significant decrease in systolic as well as diastolic blood pressure both after administration of potassium hydrogen carbonate and citrate. CONCLUSION: The results confirm previous studies showing a relation between acid conditions in the body and the excretion of calcium and add new data on magnesium. A blood pressure decrease after potassium has been found in previous studies. This suggests an alternative for the treatment of moderately increased levels of blood pressure that should be further explored. |
| | |
Authors:
|
Ragnar Rylander; Tommi Tallheden; Jürgen Vormann |
Related Documents
:
|
2992854 - Potentiation of acth hypertension in man with salt loading. 17534464 - Dietary sodium and cardiovascular outcomes: a rational approach. 9453264 - Relation of urinary sodium excretion to blood pressure, glucose metabolism, and lipid m... 6400114 - Clinical biochemical and haemodynamic correlates of sodium sensitivity in essential hyp... 10744354 - Persistent improvement of cardiovascular risk factors in spontaneously hypertensive rat... 6219074 - Acute effect of thymoxamine on aqueous humor formation in the epinephrine-treated norma... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Magnesium research : official organ of the International Society for the Development of Research on Magnesium Volume: 22 ISSN: 0953-1424 ISO Abbreviation: Magnes Res Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8900948 Medline TA: Magnes Res Country: England |
Other Details:
|
Languages: eng Pagination: 262-5 Citation Subset: IM |
Affiliation:
|
BioFact Environmental Health Research Center, Lerum, Sweden. envhealth@biofact.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of MgSO 4 on FEV 1 in stable severe asthma patients with chronic airflow limitation.
Next Document: Magnesium concentration in the cerebrospinal fluid of mice and its response to changes in serum magn...