Document Detail

Acid-base balance and weight gain: are there crucial links via protein and organic acids in understanding obesity?
MedLine Citation:
PMID:  19410381     Owner:  NLM     Status:  MEDLINE    
Obesity is associated with ever increasing social costs posing a general public health challenge. The most obvious reason for obesity, given healthy body functioning, is a positive calorie balance. This article delves into the lesser studied realm of the relationship of weight gain, in particular adipose tissue gain, with increased hydrogen ion concentration, taking protein and organic acids as important caveats in this discussion. The review opens the topic with the contradictory result of various studies reporting a positive relationship between chronic metabolic acidosis and weight loss. It goes to explain a process of weight gain, primarily adipose tissue gain, on acidogenic diets. Insufficient dietary protein could lead to muscle loss, and individual organic acids might indicate if there is any fatty acid oxidation or accumulation of hydrogen ion. The solution to the acid accumulation is discussed not in protein limitation but an increase in the consumption of vegetables and fruits. Finally, this review article based on studies published puts forward a physiological basis including a hypothesis to explain the possible link between hydrogen ion concentration and weight gain. This link could possibly explain the development of diseases and aging partially, and warrants research.
Shoma Berkemeyer
Publication Detail:
Type:  Journal Article     Date:  2009-05-01
Journal Detail:
Title:  Medical hypotheses     Volume:  73     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-10     Completed Date:  2009-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-56     Citation Subset:  IM    
Ruhr-Universität-Bochum, Klinik für Altersmedizin und Frührehabilitation, Studienbüro, Room 23, Widumerstr. 8, 44627 Herne, Germany.
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MeSH Terms
Acid-Base Equilibrium
Acids / administration & dosage*
Administration, Oral
Dietary Proteins / metabolism*
Models, Biological*
Obesity / physiopathology*
Organic Chemicals / administration & dosage*
Weight Gain*
Reg. No./Substance:
0/Acids; 0/Dietary Proteins; 0/Organic Chemicals

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