Document Detail

Acid-base balance in peritoneal dialysis.
MedLine Citation:
PMID:  16736431     Owner:  NLM     Status:  MEDLINE    
In patients without functioning kidneys, alkali replenishment is accomplished by the addition, via dialysis solution, of either HCO 3 - itself or a metabolic precursor of this anion, such as lactate. The body base balance in peritoneal dialysis (PD) patients is self-regulated by the feedback between plasma bicarbonate concentration and dialytic base gain. Dialytic base gain is the only source of buffer for PD patients and this gain should counteract the metabolic acid production. Dialytic base gain depends on peritoneal buffer fluxes (lactate reabsorption minus bicarbonate lost). The plasma bicarbonate level is determined by the dialytic base gain and the metabolic acid production. Bicarbonate buffered PD solution provides some advantages over the conventional lactate buffered PD solution.
R Dell'Aquila; M P Rodighiero; E Spanò; M Feriani; C Ronco
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of nephrology     Volume:  19 Suppl 9     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-05-31     Completed Date:  2006-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S104-7     Citation Subset:  IM    
Department of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, Vicenza, Italy.
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MeSH Terms
Acetates / blood
Acid-Base Equilibrium / physiology*
Acidosis / blood,  etiology
Bicarbonates / blood
Kidney Failure / blood,  therapy
Lactates / blood
Peritoneal Dialysis*
Risk Factors
Reg. No./Substance:
0/Acetates; 0/Bicarbonates; 0/Lactates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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