| Acid and barriers. Current research and future developments for peptic ulcer therapy. | |
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MedLine Citation:
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PMID: 1978405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medical therapy for peptic ulcer disease has been targeted at inhibiting acid secretion based on the belief that ulcers occur due to an imbalance between aggressive and protective factors. New antisecretory agents are unlikely to show any dramatic improvement over the success and safety of histamine H2 receptor antagonists or the recently introduced H+K+ATPase proton pump antagonist omeprazole. The development of specific muscarinic M3 and gastrin receptor antagonists will provide useful agents to suppress acid and pepsinogen secretion by alternative means and may prevent the associated hypergastrinaemia seen with anti-secretory therapy. Enhancement of mucosal defence by site protective agents will be based on a better understanding of the vascular and immune factors involved in maintaining mucosal integrity and the growth factors that regulate wound healing. Molecular techniques are likely to produce the 'model anti-ulcer' agent which will effectively inhibit acid secretion and also enhance wound healing thus providing a cure for this chronic disease. |
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Authors:
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J W Rademaker; R H Hunt |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 175 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-12-05 Completed Date: 1990-12-05 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 19-26 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antacids
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therapeutic use* Anti-Ulcer Agents / therapeutic use* Gastric Mucosa / physiology Helicobacter Infections / complications Helicobacter pylori Histamine H2 Antagonists / therapeutic use Humans Intestinal Mucosa / physiology Peptic Ulcer / drug therapy*, etiology Wound Healing / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Anti-Ulcer Agents; 0/Histamine H2 Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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