Document Detail

Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells.
MedLine Citation:
PMID:  21321108     Owner:  NLM     Status:  MEDLINE    
As an H(+)-gated subgroup of the degenerin/epithelial Na(+) channel family, acid-sensing ion channels (ASICs) were reported to be involved in various physiological and pathological processes in neurons. However, little is known about the role of ASICs in the function of dendritic cells (DCs). In this study, we investigated the expression of ASICs in mouse bone marrow-derived DCs and their possible role in the function of DCs. We found that ASIC1, ASIC2, and ASIC3 are expressed in DCs at the mRNA and protein levels, and extracellular acid can evoke ASIC-like currents in DCs. We also demonstrated that acidosis upregulated the expression of CD11c, MHC class II, CD80, and CD86 and enhanced the Ag-presenting ability of DCs via ASICs. Moreover, the effect of acidosis on DCs can be abolished by the nonsteroidal anti-inflammatory drugs ibuprofen and diclofenac. These results suggest that ASICs are involved in the acidosis-mediated effect on DC function.
Jing Tong; Wen-Ning Wu; Xiaoling Kong; Peng-Fei Wu; Li Tian; Wenjiao Du; Min Fang; Fang Zheng; Jian-Guo Chen; Zheng Tan; Feili Gong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-14
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  186     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-03     Completed Date:  2011-05-26     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3686-92     Citation Subset:  AIM; IM    
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
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MeSH Terms
Acidosis / immunology*,  metabolism*,  pathology
Animals, Newborn
Cell Differentiation / immunology
Cells, Cultured
Dendritic Cells / cytology,  immunology*,  metabolism*
Extracellular Space / immunology*,  metabolism*
Hydrogen-Ion Concentration
Mice, Inbred BALB C
Mice, Inbred C57BL
Nerve Tissue Proteins / biosynthesis,  physiology*
Rats, Sprague-Dawley
Sodium Channels / biosynthesis,  physiology*
Reg. No./Substance:
0/ASIC channel; 0/Nerve Tissue Proteins; 0/Sodium Channels
Comment In:
J Immunol. 2011 Jun 15;186(12):6647   [PMID:  21646300 ]

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